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Managing HAE Attacks

HAE can be managed with 2 types of treatment

Even if you’re on preventative therapy, you should always have an on-demand HAE treatment (also known as rescue or acute therapy) on you so you can respond to attacks if and when they happen. If you aren’t currently prescribed an on-demand treatment, talk to your doctor about your options.


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    Preventative treatment

    Preventative treatment is taken regularly
    with the goal of reducing the number and
    severity of HAE attacks.

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    On-demand treatment

    On-demand treatment is used to treat HAE
    attacks as they occur and can help reduce
    their length and severity.

Preventative therapies alone do not eliminate the burden of HAE attacks

Attacks cause significant disruptions to the lives of people with HAE, requiring them to modify their lifestyles and daily routines.

  • In one study,

    90% of people

    on preventative treatment reported still
    experiencing attacks
    in the previous 12 months

  • On average, people on preventative
    treatment requested

    14 doses

    of on-demand treatment per year

Injectable on-demand therapies come with their own set of challenges

On-demand treatment is a necessary part of HAE management and works best when taken at the first sign of symptoms, but many people receiving injectable on-demand therapy often delay treatment or don’t treat attacks at all.

  • 3.8 hours

    was the average time people with HAE
    waited to treat an attack*

  • 57%

    of people with HAE do not treat all
    their attacks, which may lead to prolonged
    swelling and pain

*Results from a 2023 HAE Association survey of 94 people taking either on-demand treatment or both on-demand and preventative treatment.

Results from a 2022 HAE Association survey of 107 people taking either on-demand treatment or both on-demand and preventative treatment.

On-demand treatments can halt attack progression, but
it takes time for your body to clear the swelling. Treating as early as
possible can lead to less severe attacks and a faster recovery.

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS EKTERLY® (sebetralstat)?

EKTERLY is a prescription medicine used to treat sudden (acute) attacks of hereditary angioedema (HAE) in adults and children aged 12 years of age and older. It is not known if EKTERLY is safe and effective in children under 12 years of age.

IMPORTANT SAFETY INFORMATION

Before taking EKTERLY, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or planning to become pregnant. It is not known if EKTERLY can harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if EKTERLY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking EKTERLY.
  • Have liver problems.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking EKTERLY with certain other medicines can cause side effects or affect how well EKTERLY or the other medicines work. Especially tell your healthcare provider if you take any of the following, as their use with EKTERLY is not recommended: itraconazole, phenytoin, efavirenz.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

What are the possible side effects of EKTERLY?

The most common side effects of EKTERLY include headache. For more information, ask your healthcare provider or pharmacist. Talk to your doctor for medical advice about side effects.

You are encouraged to report side effects related to KalVista products by calling 1-855-258-4782. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Patient Information.