This website is intended for US residents.

For Healthcare Providers
Real EKTERLY® (sebetralstat) patient Zach sitting on a bench Real EKTERLY® (sebetralstat) patient Zach sitting on a bench

How
EKTERLY
Works

ZACH, real EKTERLY patient

EKTERLY halts the attack

EKTERLY works by blocking plasma kallikrein, which is a protein that plays a key role in swelling in hereditary angioedema (HAE) attacks.

  • Plasma kallikrein

    In people with HAE, plasma kallikrein becomes overactive.

  • Excessive fluid leaking through blood vessels

    When plasma kallikrein is overactive, excessive fluid leaks through the walls of blood vessels and into body tissues.

  • Excessive fluid

    Increased fluid buildup leads to the swelling that people with HAE experience during an attack.

  • EKTERLY® (sebetralstat) blocking plasma kallikrein

    EKTERLY works to stop attacks from getting worse by blocking plasma kallikrein.

Once taken, EKTERLY begins blocking plasma kallikrein in as little as

30
minutes (phase 1 trial)
15
minutes (phase 2 trial)

These findings are based on people who received the
600-mg dose in early clinical studies
(6 people in phase 1 and 12 people in phase 2)

Learn more about EKTERLY, including study results, safety information, and additional support.

Download Patient Brochure download icon
Real EKTERLY® (sebetralstat) patient Ellis waving to his mother in a car Real EKTERLY® (sebetralstat) patient Ellis waving to his mother in a car
UP NEXT:
Taking EKTERLY Right arrow
ELLIS, real EKTERLY patient

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS EKTERLY® (sebetralstat)?

EKTERLY is a prescription medicine used to treat sudden (acute) attacks of hereditary angioedema (HAE) in adults and children aged 12 years of age and older. It is not known if EKTERLY is safe and effective in children under 12 years of age.

IMPORTANT SAFETY INFORMATION

Before taking EKTERLY, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or planning to become pregnant. It is not known if EKTERLY can harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if EKTERLY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking EKTERLY.
  • Have liver problems.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking EKTERLY with certain other medicines can cause side effects or affect how well EKTERLY or the other medicines work. Especially tell your healthcare provider if you take any of the following, as their use with EKTERLY is not recommended: itraconazole, phenytoin, efavirenz.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

What are the possible side effects of EKTERLY?

The most common side effects of EKTERLY include headache. For more information, ask your healthcare provider or pharmacist. Talk to your doctor for medical advice about side effects.

You are encouraged to report side effects related to KalVista products by calling 1-855-258-4782. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Patient Information.